Articles Accepted

Effect of Olmesartan on Pharmacodynamic and Pharmacokinetics of Glimepiride and Metformin combination in animal models
by Dr. Beere Nagaraju, 18 Feb 2020

To establish the safety and efficacy of the drug-drug combinations in diabetic hypertensive patients, the present study was designed to identify the pharmacodynamic and pharmacokinetic influence of Olmesartan on Glimepiride+Metformin combination in normal rats, diabetic rats and normal rabbits using treatment of single and multiple doses. Blood samples were analyzed for blood glucose by GOD/POD method, insulin by ELISA, serum Glimepiride levels by HPLC method at pre-determined time intervals. The Olmesartan showed significant synergistic hypoglycemic activity with Glimepiride + Metformin as well as elevated serum insulin levels in single and multiple-dose combinations in both rats and rabbits. The pharmacokinetic interactions of this combination are evidenced by a significant increase in AUMC0-t, AUMC0-∞, MRT and there is a decrease in clearance (Cl) of Glimepiride + Metformin with the single and multiple-dose treatment of Olmesartan. Hence, care must be taken by physicians while prescribing Olmesartan and Glimepiride+Metformin combination in a clinical situation.

Current Issue
Quick Contact