Articles Accepted

Hepatoprotective activity of whole flower of Hibiscus rosa-sinensis Linn extracts in wistar rats
by Mr. Krishn Kumar Agrawal, 20 Feb 2020

The aim of the present study was to evaluate the hepato protective effect of ethanol and aqueous extracts of Hibiscus rosa-sinensis Linn flowers. Carbon tetrachloride-induced hepatic injury in rats and pentobarbitone induced hypnosis methods were used to evaluate the hepatoprotective activity. Alteration in biochemical parameters of hepatic damage like alanine transminase (ALT), aspartate transminase (AST), alkaline phosphatase (ALP), triglycerides (TG), cholesterol, total bilirubin, direct bilirubin and pentobarbitone induced sleeping time were tested in different group of study. Carbon tetrachloride (1ml/kg i.p.) has enhanced the level of biochemical markers of hepatic damage and increase the sleeping time in mice. Treatment with ethanol and aqueous extracts of Hibiscus rosa-sinensis flowers (200mg/kg and 400mg/kg) has significantly back the altered levels of biochemical markers to the almost near normal level in the dose dependent manner as compared to silyamarin (100mg/kg) and control group (1% w/v CMC). The result concludes that hepato protective activity is may be due to the presence of flavonoids, mucilage, tannins or alkaloids which justify its folkloric use of Hibiscus rosa-sinensis.

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