Articles Accepted

This study presents a novel nanotherapeutic strategy for the treatment of arthritis utilising copper nanoparticles (CuNPs) prepared using leaf extract from Baliospermum solanifolium. Known for its anti-inflammatory properties, the plant was used as a natural capping and reducing agent during the development of nanoparticles. FTIR, XRD, SEM, and UV-Vis spectroscopy were utilised to thoroughly evaluate the size, shape, and structural integrity of the green-synthesised copper nanoparticles. The anti-inflammatory qualities were assessed in vivo using a carrageenan paw oedema model in rats. The copper nanoparticle gel formulation showed significantly superior anti-arthritic activity. These results suggest that a topical gel containing CuNPs derived from Baliospermum solanifolium provides a safe and efficient nanotherapeutic alternatives for the treatment of arthritis symptoms, with promising potential.