Articles Accepted

Polycystic ovarian syndrome (PCOS) is a hormonal disorder affecting women of reproductive age, characterized by hormonal imbalance, cystic ovaries, and irregular menstruation. Pimenta dioica, a traditional medicinal plant, was evaluated for its therapeutic potential against PCOS using in-silico approaches. GC-MS analysis identified key phytocompounds, which were further assessed through network pharmacology, drug-likeness, ADMET, and molecular docking studies. Network analysis revealed five crucial PCOS-associated targets: Insulin receptor substrate-1 (1QQG), Androgen receptor (1E3G), Follicle-stimulating hormone (1XWD), Leptin receptor (3V60), and CYP17 (3RVK). Among the identified compounds, eugenol exhibited strong binding affinity towards these targets. ADMET profiling and PASS prediction confirmed its favorable pharmacokinetics, non-toxicity, and non-carcinogenic properties. These findings suggest that Pimenta dioica, particularly eugenol, holds promise as a potential lead compound for developing novel early-stage therapeutics for PCOS management.