In order to encourage R & D in the country, IDMA has instituted "Research Awards for the Best Original Research Articles" published in the "Indian Drugs" every year, from the year 1981-82, in the following disciplines:
The award is in the form of a citation and a cash award of Rs. 2500/- in each discipline.
Awards are presented to the recipients at the time of the Annual Celebrations of IDMA every year.
An Award for the Best Review Article in the form of a citation and special cash Award of Rs. 5000/- is presented at the time of the Annual Celebrations.
No award this year.
| Paper | : | Synthesis, Antimalarial Activity and QSAR Studies of Chalcones, N- Benzylidenesulphonamides and Chalcone Sulfonamides |
| Authors | : | More A.H., Raul S.J. and Mahajan S.S. |
| Institute | : | C. U. Shah College of Pharmacy, S. N. D. T. Women’s University, Sir Vithaldas Vidya Vihar, Juhu Road, Santacruz (West), Mumbai- 400 049 |
| Volume | : | 49 (05) |
| Page nos. | : | 20 - 34 |
| Abstract | : | Malaria remains the major cause of human morbidity and mortality worldwide. Malaria, caused by Plasmodium species, is potentially life threatening, increasing in prevalence and becoming even more resistant to in-use drugs. In this article, synthesis of compounds from the series of chalcones, benzylidenesulfonamides and chalconesulfonamides, by the conventional and microwave-irradiation methods is discussed. The microwave-irradiation method was convenient, rapid and high yielding as compared to the conventional method of synthesis. The acute oral toxicity studies indicated that all the compounds were safe for administration up to 2000 mg/kg body weight of a mouse. The compounds were screened for their antimalarial activity. Two chalcones, five benzylidenesulfonamides and three chalconesulfonamides showed antimalarial activity equivalent to chloroquine. Benzylidenesulfonamides showed better antimalarial activity compared to the compounds from the other two series. Chalconesulfonamides showed better antimalarial activity than chalcones. The QSAR studies were carried out by correlating antimalarial activity of all the compounds with their physicochemical descriptors. Validation of the best QSAR model was carried out using the training set and the test set method. These studies provided guidance for the development of novel antimalarials from these series. |
| Paper | : | Effect of Immunomodulatory Herbal Medicinal Preparations on CD4+ Lymphocyte Count and Total Viral Load in HIV- Infected Individuals |
| Authors | : | Tharakan S.T., Kuttan G, Kuttan R, Kesavan M., Sr. Austin and Rajagopalan K. |
| Institute | : | Amala Cancer Research Center, Amala Nagar, Trissur- 680555, Kerala |
| Volume | : | 49 (07) |
| Page nos. | : | 42 – 48 |
| Abstract | : | This study was carried out to determine the effect of herbal medication on the clinical status of HIV infected persons especially on their CD4+ T lymphocyte count and viral load. The toxicity of the medication was also studied. 25 HIV positive individuals were taken for the study. They were treated with a herbal formulation developed in our centre, for one year. Patients were evaluated for their clinical status every month and CD4+ T lymphocyte and viral load every six months. Other parameters assessed were body weight, hematological analysis and hepatic and renal function tests. Body weight was found to be increased in 20 patients out of 25 who have undergone treatment. CD4+T lymphocyte count was increased in 15 patients and viral load was decreased in 20 patients. In six patients viral load was undetectable range. Administration of these medications significantly reduced, elevated interferon-γ and tumor necrosis factor in HIV patients. Medication did not produce any toxicity in HIV patients, as it did not show any significant change in hepatic function, renal function and haematology. Administration of herbal preparation was found to reduce clinical symptoms produced by HIV infection. This herbal formulation was found useful therapeutically for the management of HIV infection and did not produce any toxicity. |
| Paper | : | Development and Characterization of Elementary Osmotic Pump Tablets for Simultaneous Release of Metformin and Glipizide |
| Authors | : | Bharadwaj P., Upaddhyay P.K., Agarwal V., Chaurasia D., Chaurasia H. and Singh R. |
| Institute | : | Adarsh Vijendra Institute of Pharmaceutical Science, Babu Vijendra Marg, Gangoh – 247 341, Saharanpur, (U.P.) |
| Volume | : | 49 (11) |
| Page nos. | : | 19 – 29 |
| Abstract | : | The aim of present study was to design and evaluate an elementary osmotic pump-based drug delivery system for controlled release of metformin and glipizide simultaneously for treatment of type II noninsulin dependent diabetes mellitus. Inclusion complex of glipizide with β- cyclodextrin was prepared to enhance its solubility. Core tablets were prepared by wet granulation method. Effects of different variables like amount of plasticizer, osmogen, orifice size and dissolution media were studied on release profile for both drugs. Morphology of semi permeable was studied using electron microscope before and after dissolution test. On increasing the amount of osmogen, the release of both drugs was found to be increased. No significant effect of PVP K 30 was observed on drug release. Optimization results indicated that the release of both drugs was directly proportional to the surface porosity of the membrane. It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance. |
| Paper | : | Quantitation of Carvedilol Oxidative Metabolites in Human Plasma using Liquid Chromatography–Tandem Mass Spectrometry |
| Authors | : | Valarmathy J., Sudha T., Joshua S.L. and Senthil Kumar K.L. |
| Institute | : | Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode-638112. |
| Volume | : | 49 (02) |
| Page nos. | : | 37 - 44 |
| Abstract | : | A sensitive and efficient method was developed for the determination of carvedilol and its metabolite in human plasma by LC-MS/MS. Plasma samples were hydrolysed with β-glucuronidase and the target compounds were extracted with liquid liquid extraction using diethyl ether in dichloro methane as solvent. The extracts were completely derivatized and analysed by LC-MS/MS. The linearity of the assay ranges from 0.250 ng/mL to 200.0 ng/mL for carvedilol and from 0.500 ng/mL to 30.0 ng/mL for 4-hydroxy carvedilol. The absolute recovery of carvedilol and its metabolite added to blank plasma sample was 70.28 – 82.90%. The reproducibility was from 0.96 to 8.28 for the intraday assay and from 1.65 to 6.09 for the interday assay precision. Repetitive thawing and freezing did not have an affect on metabolite through a minimum of three cycles. Thawed samples remaining in plasma for 4h before extraction were with 5% of theoretical value. Stability of the extracted samples on the auto sampler at room temperature was evaluated for 34 h and was observed to with in 12% of a fresh analytical sample for 4–hydroxy carvedilol. The proposed LC-MS/MS method was effective for the determination of carvedilol and it metabolite in human plasma. |
No award this year.
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