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The pharmaceutical industry has fostered long-term associations with many industries such as engineering, chemicals, polymers, fine chemicals, instrumentation, and more recently Information Technology, Cloud Computing and even Machine Learning and Artificial Intelligence. How...

Bioelectronic medicines (BEMs) use electrical impulses to modulate neural circuits and restore physiological function. This emerging field combines molecular medicine, neuroscience, engineering and computing to deliver precise and personalized therapies for chronic and complex disorders. Applicat...

The present study focuses on the rational design and evaluation of novel phthalazine derivatives as potential inhibitors of vascular endothelial growth factor receptor-2 (VEGFR-2), a critical target in anti-angiogenic cancer therapy. VEGFR-2 plays a pivotal role in tumor progression by promoting ...

The drug baricitinib exhibits poor bioavailability issues as a Janus kinase inhibitor, thus requiring specialized delivery methods to enhance its therapeutic performance. A 3² factorial design was used to develop solid lipid nanoparticles (SLNs) by varying coating agent Precirol® ATO5 and surfa...

This study developed silymarin-loaded multi-walled carbon nanotubes (SIL-MWCNTs) to improve hepatic cancer treatment. Silymarin, a flavonoid with hepatoprotective properties, faces challenges in conventional therapy due to poor solubility and bioavailability. The research aimed to enhance its bio...

Leflunomide HCl is an immunomodulatory drug used in the treatment of rheumatoid arthritis by inhibiting T-cell proliferation. The aim of this study was to develop and validate green chromatographic techniques for the quantitation of leflunomide HCl and its degradation products under various stres...

For ages, plants have been part of the solution for human ailments. Impatiens walleriana (Family: Balsaminaceae) is a decorative plant and its parts are edible and medicinal. Its healing potential is backed by ethnopharmacological data. Infections with parasitic worms are a threat to public healt...

Coumarins are dietary antioxidants found in plant-based foods, such as vegetables and fresh and dried fruits. Different degrees of coumarin toxicity have been reported, including cytotoxic effects, breathlessness, tremors, and sensitivity to sunlight. Plants contain diverse coumarins, and umbelli...