Technological attempts have been made in the research and development of rate controlled oral drugdelivery systems to overcome physiological adversities, such as short gastric residence times (GRT) andunpredictable gastric emptying times (GET). Several approaches are currently utilized in the pro...

The present study was aimed at the overall improvement in the efficacy, reduced toxicity andenhancement of therapeutic index of aceclofenac. Niosomal delivery system of aceclofenac has beendeveloped by various techniques using mixture of Span 60/40 (surfactant) along with cholesterol in1:1 ratio....

Benzotriazole-1-acetic acid was coupled with amino acid methyl esters/ dipeptides/ tripeptides/tetrapeptides in the presence of DCC as a coupling agent and NMM as a base under continuous stirringfor 36 hrs. The reactions were monitored by TLC. The newly synthesized compounds were analyzedand the ...

Ofloxacin, a second generation fluoroquinolone, shows poor aqueous solubility and dissolution profile. Thus, ofloxacin–β-cyclodextrin complexes were prepared to improve its dissolution by imparting an environment of improved hydrophilicity. Ofloxacin was complexed ...

A series of novel 2-oxo-1,2,3,4-tetrahydroquinolin-7-yl benzoate derivatives were synthesised and obtained in moderate yields (55-85%) by the reaction of parent 7-hydroxy-1,2,3,4-tetrahydroquinolin- 2-one (7-hydroxy-3,4-dihydroquinolin-2(1H)-one) with substituted benz...

Hepatoprotective activity of ethanolic and aqueous extracts (200 and 400 mg/kg b.w.) of Nelumbo nucifera Gaertn. (NNE and NNA respectively) was evaluated by paracetamol and Isoniazid-rifampicine (INH-RMP) induced hepatotoxicity models. In paracetamol induced hepatoxic...

The aim of present investigation was formulation and in-vitro evaluation of in situ gel for the nasal delivery of zolmitriptan. The in situ gel was prepared by temperature induced gelation technique using Pluronic with mucoadhesive polymer hydroxy propyl methyl cellul...