Table of Contents

December  2021

  • Volume 58
  • Issue 12
  • Page Nos. 94

ISSN: 0019-462X (print)

Editorial

RNA BASED THERAPIES - A POSITIVE OUTCOME OF COVID-19

PAGE 5-6

Dear Reader,

It was way back in December 2014 that Ella Watson-Stryker was named TIMES Person of the Year for 2014 and featured on the Cover of Time Magazine. Dr Watson-Stryker was recognised with the honour, which she shared with all the healthcare workers who, under trying circumstances...

Dr. George Patani

Associate Editor

Indian Drugs

Review Article

USE OF ARTIFICIAL INTELLIGENCE IN IN SILICO DRUG DISCOVERY OF PHARMACEUTICALS

PAGE 7-15

Artificial intelligence, a machine-learning process, builds a smart machine that simulates the performance of the human brain and possesses the capability of utilizing a massive amount of data required to achieve a specific goal through learning and problem solving. The idea of artificial intelli...

Sayani Bhattacharyyaa* and Kavya H. Ramakrishnaa

Original Research Articles

SYNTHESIS AND ANTICANCER ACTIVITY OF N-SUBSTITUTED INDOLE DERIVATIVES

PAGE 16-21

Thizolidine-2,4-dione (1), on reaction with p-fluorobenzaldehyde in the presence of piperidine and toluene, gives (Z)-5-(2-fluororobenzylidin)-thiazolidin-2,4-dione (2), which on reaction with indole and o-chlorobenzaldehyde in the presence of ethanol yielded final derivatives i...

Nitin Kumara* and Sanjay Sharmab

PREPARATION AND EVALUATION OF ACTIVE FILM COATING TABLET OF TENELIGLIPTIN HYDROBROMIDE HYDRATE WITH METFORMIN HYDROCHLORIDE FIXED DOSE COMBINATION

PAGE 22-31

The aim of the present study was to formulate fixed-dose combination tablets of metformin hydrochloride and teneligliptin hydrobromide hydrate. The extended-release core tablet consisted of a seal coating over metformin and outer layer coated by teneligliptin for immediate release using perforat...

Kumaravelrajan R.a*, Thirumaran M.b, Sangavi Ta and Suba V.c

PHARMACOGNOSTICAL, PRELIMINARY PHYTOCHEMICAL AND IN VITRO ANTIOXIDANT EVALUATION OF THE AERIAL PARTS OF CYPHOSTEMMA SETOSUM (ROXB.)

PAGE 32-43

The objective of the investigation presented here is to explore the pharmacognostical nature, phytochemical characterization and in vitro antioxidant activity of Cyphostemma setosum (Roxb.). Vitis setosa (Roxb.) synonymous to C. setosum (Roxb.), is a herbaceous...

Viswanath K.a , Binoy C. Varghesea * and Vijey Aanandhi M.a

STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE IN PHARMACEUTICAL FORMULATION

PAGE 44-53

A sensitive, selective, precise and accurate stability-indicating high-performance thin layer chromatographic method for analysis of budesonide (BUD) and formoterol fumarate dihydrate (FFD) was developed along with forced degradation study and validated according to ICH guidelines. Densitometry a...

Priyanka S. Shaha , Chaitali G. Patela , Kalpana G. Patela * and Tejal R. Gandhib

STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE AND DOLUTEGRAVIR IN BULK AND TABLET DOSAGE FORM

PAGE 54-62

A rapid high-performance liquid chromatographic method has been developed and validated for quantification of lamivudine and dolutegravir, used to manage HIV infections. Lamivudine and dolutegravir are separated as symmetrical peaks on the analytical column Inertsil ODS, 150 mm x 4.6 mm, 5.0 µm ...

Sakuntala Satya Venkata M.a *, Lakshmana Rao A.b and William Carey M.c

STUDY OF ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF WITHANIA COAGULANS FRUITS IN STREPTOZOTOCIN INDUCED NON-INSULIN DEPENDENT DIABETES MELLITUS IN RATS

PAGE 63-71

Withania coagulans Dunal (fam. Solanaceae) is an indigenous plant used traditionally for the treatment of diabetes and associated complications. However, the mechanistic approach of antihyperglycemic potential of the plant is not scientifically validated. The present study was undertaken...

Deepti D. Bandawanea * and Archana R. Juvekarb

Short Communications

NEVIRAPINE SOLID DISPERSION: DESIGN, DEVELOPMENT AND EVALUATION

PAGE 72-74

The objective of the present investigation was to enhance the solubility and dissolution rate of BCS class II drug nevirapine through scalable and commercially feasible solid dispersion approach by using Soluplus® (BASF) as hydrophilic carrier. The solid dispersion produced by melting...

Prabhakar Panzadea* and Giridhar Shendarkarb

STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN AND LINAGLIPTIN IN PHARMACEUTICAL DOSAGE FORM

PAGE 75-78

A simple, specific, accurate, precise and stability indicating high performance liquid chromatographic method was developed and validated for the simultaneous estimation of empagliflozin and linagliptin using Thermo Scientific BDS C18 column (250 ×4.6 mm, 5 µm) with mobile phase cons...

Hemant T. Kumara * and Gowri D. Sankarb

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