The colon specific drug delivery system is gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein & peptide drugs. Colon was considered as black-box as most of the drugs are absorbed from upper part of the GI tract. Colon targeting was aimed...

1, 3, 4-oxadiazoles were synthesized by treating pyrazine-2-carbohydrazide with CS2 and alc. KOH and their derivatives were prepared by using R-Cl compounds. pyrazolones were synthesized by treatingpyrazine-2-carbohydrazide with ethyl acetoacetate. The derivatives of pyrazolone were prepared by r...

A new series of substituted benzimidazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral data. The title compounds were evaluated for antimicrobial activity. Some of these compounds have shown excellent antimicrobial activity.

In the present work an attempt has been made to analyze quantitatively the content of vitexin in Oxalis corniculata leaves and its protective activity on gentamicin and cisplatin induced nephrotic damage in albino rats. Vitexin is 8-beta-D glucopyranosyl apigenin found commonly in Oxalis cornicul...

The study was aimed to evaluate wound healing activity of 70% ethanolic and methanolic extracts of leaves of Wrightia tinctoria (Roxb) R. Br (Apocynaceae) using incision and excision wound models on Wistar rats. Wound contraction and period of epithelization were assessed in excision wound model ...

Telmisartan is used in the treatment of hypertension. It exhibits poor water solubility. It belongs to class II of Biopharmaceutical Classification system (BCS). It needs enhancement in dissolution and hence bioavailability. The dissolution of drug was improved by coating the drug and carrier ove...

Different extracts of aerial parts of Portulaca oleracea L. were evaluated for their anthelmintic activity on adult Indian earthworms, Pheretima posthuma, among which ethanol extract was found more potent.Their activities are comparable with the reference drug albendazole. The result supports the...