Table of Contents

April  2025

  • Volume 62
  • Issue 4
  • Page Nos. 76

Guest Editorial

EDITORIAL: ADVANCED INNOVATION AND RESEARCH – A NEED OF THE HOUR

PAGE 5-6

Dear Reader,

Pharmacy a unique profession in the dynamic world of healthcare, is pivoted at the intersection of science and technology which addresses the crucial needs of healthcare. Healthcare is continuously ridden with plentiful challenges, which could lead to serious consequences if ...

Dr. Padma V. Devarajan, FMAS

ex-Dean Research & Innovation,

Sr. Prof. in Pharmacy & former Head

Dept. of Pharmaceutical Sciences & Technology,

ICT, Mumbai.

Review Article

A COMPREHENSIVE REVIEW ON MULTI-DRUG COCRYSTALS

PAGE 8-19

Multi-drug cocrystals (MDCs) have gained increasing interest in recent times. They are also known as drug-drug cocrystals. MDCs offer a promising approach in pharmaceutical development, where two or more active pharmaceutical ingredients (APIs) are cocrystallized with a neutral coformer to create...

Monika Nijhawana *, Bhavana Jidigea , Pavan Kumar Thotaa , Rajeswari Aletia and Neelima Rambakkaa

Original Research Articles

STRUCTURE-BASED DESIGN, IN SILICO ADME, SYNTHESIS AND IN VITRO PHARMACOLOGICAL SCREENING OF COUMARIN CHALCONE ANALOGUES AS EGFR INHIBITORS FOR NON-SMALL CELL LUNG CANCER

PAGE 20-29

Non-small cell lung cancer (NSCLC) primarily reveals overexpression of epidermal growth factor receptors (EGFR), driving uncontrolled and abnormal cell divisions in lung tissue. Gefitinib is a firstgeneration EGFR inhibitor that is widely used as first-line NSCLC treatment, hence PDB ID 4I22 was ...

Archanadevi A. Patela and Archana S. Gurjara *

FORMULATION AND CHARACTERIZATION OF pH-INDUCED IONIC GELATION CIMETIDINE ORAL IN SITU GEL FOR TARGETED GASTRIC DELIVERY

PAGE 30-36

Cimetidine is an orally administered anti-ulcer medication. This study aims to develop a gastro-retentive in situ gel containing the drug to enhance its oral bioavailability and provide prolonged release. The gel was prepared by incorporating an emulsion into a polymeric solution, resulting in a ...

Chetan Kumar Shettya , Sheeba F. Roseleta * and Navyashree Gowdaa

DESIGN OF EXPERIMENT BASED UV-SPECTROPHOTOMETRIC METHOD FOR QUALITY CONTROL ANALYSIS OF SILYMARIN IN MARKETED TABLET FORMULATION

PAGE 37-47

Silymarin is a significant medication that is used to treat chronic liver disease and liver cirrhosis. The focus of the current study is on the development of UV based analytical procedures for silymarin quantification using quality by design methodologies. Materials and procedures selected signi...

Mahesh S. Palleda *, Shailendra S. Suryawanshia , Sanit J. Revankara and Shweta M. Pandarea

MODIFICATION OF PHYSICOCHEMICAL PROPERTIES OF ALBENDAZOLE VIA FORMATION OF IONIC LIQUIDS

PAGE 48-54

The world is rife with parasitic diseases. There is a great need to develop methods to improve delivery of medicines. Solubility and chemical stability are crucial factors to be taken into account while creating medicines. Ionic liquids (ILs) are ion-based salts that melt at or are liquid at lowe...

Rushikesh M. Doijada * and Yogesh V. Porea

EVALUATION OF CARDIOPROTECTIVE EFFECT OF DAIDZEIN IN 5-FLUOROURACIL-INDUCED CARDIOTOXICITY IN WISTAR RATS

PAGE 55-60

The aim of the study was to determine the cardioprotective effect of daidzein in 5-fluorouracil-induced cardiotoxicity. The animals of the standard group were treated with carvedilol 10 mg kg-1, and DDZ5 and DDZ10 groups were treated with daidzein for 8 days at doses of 5 mg kg-1 and 10 mg kg-1, ...

Vivek Srivastavaa *, Bushra Khatoona , Utkarsh Upadhyaya and Peeush Singhalb

Short Communications

PROBING THE REVERSAL OF NATURAL COLOR PREFERENCE IN ADULT ZEBRAFISH AFTER TRIMETHYLTIN INDUCED NEURODEGENERATION

PAGE 61-64

For turmeric oil obtained from Curcuma longa L. and rosemary oil obtained from Rosmarinus officinalis L. there an limited reports for their effect against neurodegenerative disorders, besides the limited knowledge on formulation development and their evaluation for CNS disorders have tremendous f...

Suraj K. Morea and Atmaram P. Pawara *

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