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Organic bicyclo compounds contain two rings with two common atoms called as bridgehead atoms. There exist at least nine classes of substituted bicyclic hydrocarbons. Camphor and a-pinene are well-known examples containing carbon bridgehead atoms. Replacing the carbon bridgehe...

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age. Resveratrol, a phytoestrogen with multiple pharmacological properties, has shown potential in managing PCOS. This review explores the beneficial effects of resveratrol on hormonal, metabolic a...

Narcolepsy is a chronic neurological disorder marked by excessive daytime sleepiness (EDS) and sudden muscle weakness (cataplexy), severely affecting the quality of life. It involves dysregulation of sleep-wake cycles, often linked to loss of orexin-producing neurons. Current treatments manage sy...

This study was aimed to design a floating pulsatile device for a poorly water-soluble drug to reduce hypertension patients’ circadian symptoms. An inclusion complex of hydroxypropyl beta-cyclodextrin and nifedipine was created using the solvent evaporation method. The quick-release tablets were...

Indole-3-carbinol, a naturally occurring phytocompound found in cruciferous vegetables, is recognized for its biological and nutritional benefits; however, its underlying molecular mechanisms remain largely underexplored. This study employed network-based computational approaches to comprehensive...

The present work focuses on developing and validating a stability-detecting High Performance Liquid Chromatographic technique for pitolisant, utilizing Quality by Design approach while evaluating its environmental sustainability. Central composite design as a part of response surface methodology ...

Anxiety disorders affect over 33% of the global population representing a major public health concern. Hydroxyzine, an antihistamine, and ascorbic acid (Vitamin C), a powerful antioxidant, are known to have anxiety-reducing effects. This study explores their combined impact using zebrafish (Danio...

Naringenin, a flavanone widely found in citrus fruits, possesses significant antioxidant properties due to its inherent hydroxyl groups. However, poor bioavailability often limits its therapeutic application. To overcome this, three derivatives-5,4’-dihydroxy-7-ethoxyflavanone (NA1), 4’,7-dih...