Table of Contents

September  2018

  • Volume 55
  • Issue 09
  • Page Nos. 74

Guest Editorial

Domestic APIs and Intermediates – The Need of the Hour

PAGE 5-6

Dr George Patani, is a Pharmacist from the College of Pharmaceutical Sciences, Manipal and completed his Masters in Medicinal Chemistry and Ph.D. in Drug Delivery from the Rutgers, The State University of New Jersey. He has approx. 18 years’ experience at the INGA group of companies, developing...

Dr. George Patani,
Associate Editor,
Indian Drugs

Original Research Articles

Synthesis and antiproliferative activity of flavonoid derivatives: Effect of B-ring substitution

PAGE 7-14

Flavones, flavonols, flavanones and isoflavones constitute four important categories of naturally occurring flavonoids. These compounds possess good antiproliferative activity and can act as adjuvants to existing anticancer therapy. We have synthesized twenty synthetic flavonoids including flavon...

Joshi U.a*, Anantram A.a, Joshi A.a, Gokhale K.b, Shukla S.b, Sinha R.c, Srivastava S.c and Govil G.c

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL QUINOLINE BASED 2-AZETIDINONES AND 4-THIAZOLIDINONES

PAGE 15-23

The present work describes the synthesis of a series of quinoline based 4-thiazolidinone and 2-azetidinone derivatives from Schiff bases obtained from the condensation of 2-chloro-3-formylquinoline and 3-4-aminoacetophenones. Quinoline based 4-thiazolidinone and 2-azetidinone derivatives have bee...

Govindarao K.a*, Srinivasan N.b and Suresh R.b and Ravi Shankar K.c

Bioanalytical method development and validation of micronized gliclazide in human plasma by LC-MS/MS and its pharmacokinetic studies

PAGE 24-33

Drugs having poor oral bioavailability, fail to reach the minimum effective concentration required to achieve pharmacological action. Improvement of the oral bioavailability of the drug is the most realistic approach, as it is the most preferred and convenient route of administration. Besides num...

Bose R.a, b, Dan S.b, Mandal P.b, Sarkar P.b, Ghosh B.c, Ghosh L. K.d and Pal T. K.b*

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR QUANTITATIVE ESTIMATION OF PALIPERIDONE

PAGE 34-40

A planar chromatography (HPTLC) method has been developed and validated for quantitative estimation of the atypical antipsychotic drug paliperidone, which is weakly basic and poorly water soluble. The Camag HPTLC system, operated by software winCATS (ver.1.4.1.8), was used. Sample application was...

Shirode A.a*, Garade C.a and Kadam V.a

LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION OF RELATED IMPURITIES OF LURASIDONE AND ITS FORMULATION

PAGE 41-48

An RP-HPLC method was developed for the quantification of related impurities of lurasidone and its formulation. The chromatographic separation employs gradient elution using an Inertsil ODS C18 (150x4.6) mm, 5μm columns. Mobile phase consisting of solvent A-buffer (pH 3.0): methanol (90:10 %v/v)...

Kachave R. N.a*, Mandlik P. B.a and Nisal S. R.a

ISOLATION, CHARACTERIZATION AND ANTIFERTILITY ACTIVITY OF THE ACTIVE MOIETY FROM THE STEM OF MUSA PARADISIACA L.

PAGE 49-54

Bioactive principles from the hyroalcoholic (50%) extract of Musa paradisiaca L. stem were isolated and characterized to evaluate antifertility activity in female albino rats. Oral acute toxicity study was done with crude extract for 24h. The hydro alcoholic extract of M. paradisiaca stem was sub...

Soni P.a*, Siddiqui A. A.b, Dwivedi J.c and Soni V.a

Short Notes

Design of Proniosomal gel containing Eugenol as an Antifungal agent for the treatment of Oral Candidiasis

PAGE 55-57

The objective of this study was to design and investigate the antifungal activity of proniosomal gel of eugenol for the treatment of oral candidiasis. The proniosomal gel was prepared by coacervation phase separation method using different surfactants like spans 20, 60, 80, soya lecithin and chol...

Vishnu T. S.a, Dubey A.a*, Ravi G.S.a and Hebbar S.a

Toxicity studies on silver and copper NANOPARTICLES

PAGE 58-60

In a pilot scale study, silver and copper nanoparticles were synthesized from two different plant sources viz Flacourtia indica and Prosopsis juliflora. The in vivo toxicity of silver and copper nanoparticles was tested on Danio rerio (Zebra fish) under differe...

Samuel P.a*, Pavithra B.a, Priyadarshini R.a, Maheswari V.a, Vijayakumar J.a and Selvarathinam T.a

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