Table of Contents

December  2019

  • Volume 56
  • Issue 12
  • Page Nos. 86

Guest Editorial

Celebrating Lithium

PAGE 5-6

Dr. Nagaraj Narayan Rao obtained Bachelor’s degrees in Science (Chemistry) and in the Technology of Pharmaceuticals and Fine Chemicals from the University of Mumbai. After working with Colgate-Palmolive (India) for two years as a laboratory chemist, he obtained his doctorate in science with mag...

Dr. Nagaraj N. Rao
Associate Editor
Indian Drugs

Review Article

A REVIEW ON ETHNO-MEDICINAL USES, PHYTO-CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EVIDENCE OF APIUM GRAVEOLENS LINN.

PAGE 7-19

Apium graveolens Linn., popularly known as Karafs or Celery, belongs to family Apiaceae. It has been used in traditional system of medicine for a long time, for the treatment of the various ailments like bronchitis, asthma, liver and spleen diseases, gout, anuria, amenorrhoea, renal and vesicular...

Waseem M.a*, Rauf A.b and Rehman S.b

Original Research Articles

DESIGN, SYNTHESIS AND EVALUATION OF 6-SUBSTITUTED-4-HYDROXY-1-(2- SUBSTITUTEDACETYL)-3-NITROQUINOLIN-2(1H)-ONEs FOR ANTICANCER ACTIVITY

PAGE 20-27

The present work deals with the synthesis of a series of 6-substituted-4-hydroxy-1-(2-substitued alicyclicaminoacetyl)-3-nitroquinolin-2(1H)-one {IVa-d (1-3)} derivatives and evaluation of their in vitro anticancer activity. Docking study was carried out using EGFR-tyrosine kinase binding site (P...

Bhat S. S.a, MamleDesai S. N.a*, Narvekar V.a, Shingade S. G.a, Dighe P. K.b and Biradar B. S.c

SYNTHESIS AND EVALUATION OF NOVEL CHEMICAL ENTITIES AS ANTI-BREAST CANCER AGENTS

PAGE 28-31

A series of dihydropyrimidone derivatives was synthesized by an efficient, simple and solvent less green method by using Beginelli reaction. Various aromatic aldehydes, urea and ethyl acetoacetate were refluxed for a few hours and the reaction monitored by periodic TLC (hexane: ethyl acetate 6:4 ...

Nikam D.a*, Tanvar S.a, Kute A.a, Lokhande S.a and Yadav R.a

Optimization of Ultrasonic Assisted Extraction of Antioxidants from Moringa oleifera Lam. Leaves Using Response Surface Methodology

PAGE 32-38

The present study was embarked upon for the optimization of conditions aimed at ultrasonic assisted extraction (UAE) of antioxidant chemicals from Moringa oleifera leaves by applying response surface methodology (RSM) based on face centered central composite design (CCD). Evaluation was done at t...

Sholapur H. N.a*, Dasankoppa F. s.b , Abbas Z.c, Swamy N.G.N.d

Antifungal Topical Gel of Leaf Extract of Amaranthus viridis L. for Treatment of Cutaneous Candidiasis

PAGE 39-44

The objective of the study was to prepare antifungal gel using leaves of Amaranthus viridis for the treatment of cutaneous candidiasis. The leaves were studied for pharmacognostic evaluation. The powder of leaves was tested for phytoconstituents. The plant extract was evaluated for the minimum in...

Pandit A. P.a*, Khandagale K. S.a, Nakhate V. C.a and Dharmadhikari N. N.b

Quantification of Hydrazine Hydrate in Imatinib Mesylate at Genotoxic level by Chromatographic Method

PAGE 45-52

Hydrazine hydrate has genotoxic effect in nature and so it should be controlled down as Potential Genotoxic Impurity (PGI). Being polar molecule, hydrazine hydrate (N2H4.H2O) has no chromophores present in structure which can follow Lambert beer law, thus it is difficult to analyze. The present w...

Sojitra C.a,b,c, Agarwal S.b,*, Dholakia C.a, Sudhakar P.c, and Singh K. K.a

ANTIDIABETIC ACTIVITY Of METHANOLIC EXTRACT OF CUCUMIS DIPSACEUS EHRENB. (FRUIT) IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

PAGE 53-61

The present study was designed to investigate the hypoglycemic and antidiabetic properties of Cucumis dipsaceus fruit which is widely used in the Indian traditional medicine for the treatment of diabetes.Aim of present study, to investigate the antidiabetic action of the methanolic extract of C. ...

Kaur Gagandeepa, Srivastav D.a and Lata Sumana*

Short Notes

Three-dimensional QSAR modeling benzimidazole Analogues using the k-nearest neighbor method

PAGE 62-67

We undertook the three-dimensional (3D) QSAR studies of a series of benzimidazole analogues to elucidate the structural properties required for angiotensin II. The 3D-QSAR studies were performed using the stepwise, simulated annealing (SA) and genetic algorithm (GA) selection k-nearest neighbor m...

Sharma M. C.a* and Kohli D. V.a

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