ABSTRACT

This study was undertaken to investigate the in vivo wound healing activity of ethanol extracts of the aerial parts of Euphorbia hirta Linn. and its polyherbal formulation with Tridax procumbens and Eclipta alba. The in vivo wound healing activity was assessed in albino rats by using three wound models i.e. excision wound, incision wound and dead space wound models. Level of biochemical markers and histological changes were monitored to evaluate the enhancement of wound healing. The results showed that ethanolic extract ointment possesses a definite prohealing action. This was demonstrated by a significant increase in the rate of wound contraction and by enhanced epithelization. Significant increase in tensile strength, hydroxyproline content and collagen levels were observed, which was further supported by histopathological studies and gain in granuloma breaking strength.