ABSTRACT

The aim of this study was the selection of the most effective variable for the formulation of telmisartan liposomes. Liposomes were prepared by dry film deposition method using a Rota evaporator. The effects of formulation and processing variables on different response variables were studied using standard Taguchi orthogonal array L8 design. The independent variables selected were the amount of lipid, amount of cholesterol, sonication time, speed of Rota evaporator, hydration time, hydration volume and temperature, and the dependent variable selected were particle size (nm) and entrapment efficiency (%). All the batches of liposomes were prepared as per the Taguchi design. The influence of variables analyzed by Pareto ranking showed that the most effective factors for the selected responses were the amount of cholesterol, amount of lipid and sonication time (P<0.05).