ABSTRACT

The antidiabetic activity of Coptis teeta extract (CE) was investigated in a diabetic rat model. Alloxan (150 mg kg-1, i.p.) was used to induce hyperglycemia in rats. Oral administration of CE at the dose of 250 and 500 mg kg-1 for 28 days lowered the blood glucose level. Various physical parameters (body weight, food and fluid intake) and biochemical parameters like serum glucose, insulin level and kidney functions were measured. Results revealed that rats treated with CE forbade the decrease in body weight, and showed a significant (p<0.05) reduction in food and fluid intake, serum glucose, serum urea, serum creatinine, and a significant increase in insulin level and serum protein as compared to diabetic rats. Histopathological study of kidneys supported the data and CE reduced the damage to the glomerulus and bowman capsule produced by alloxan. The study clearly shows that the ethanolic extract of C. teeta possesses potent antidiabetic activity