Article Details

INFLUENCE OF ALLIUM SATIVUM ON THE ANTIHYPERGLYCAEMIC ACTIVITY OF GLICLAZIDE IN DIABETIC RATS: AN HERB-DRUG INTERACTION STUDY

Aminabee Shaika *, Ch. Rammohan Raob and Lakshmana Rao Atmakuria

a Department of Pharmacology, V. V. Institute of  Pharmaceutical Sciences, Gudlavalleru-521 356, Andhra Pradesh, India

Department of Pharmacology, Veeva Systems, Legend Platinum, Hyderabad-500 081, Telangana, India

For Correspondence: E-mail: aminaammi786@gmail.com 

 

https://doi.org/10.53879/id.60.12.13862


ABSTRACT

In this particular study, the objective was to examine how varying doses of gliclazide (1 mg kg-1) and Allium sativum (104 mg kg-1) affect interaction in rats with diabetes induced by alloxan. The diabetes was induced by intraperitoneal injection of alloxan at a dosage of 100 mg kg-1 of body weight. The results revealed that the administration of gliclazide at 1 mg kg-1 of body weight and A. sativum at 104 mg kg-1 body weight exhibited noteworthy antihyperglycemic effects. The objective was to determine whether an interaction exists between these two substances in the context of diabetic conditions. In combination the A. sativum significantly enhanced the antihyperglycaemic activity of gliclazide from 2nd to 8th h except at 4th h. Hence, there is existence of pharmacodynamic interaction between A. sativum and gliclazide.

Year 2023 | Volume No. 60 | Issue No.12 | Page No. 82-84
Recent Issue
Current Issue
May 2024
Quick Contact