Article Details

GREEN VS RED: COMPARATIVE ANALYSIS OF TERMINALIA CATAPPA LEAF EXTRACTS FOR ANTHELMINTIC ACTIVITY AGAINST PHERETIMA POSTHUMA IN AN IN VITRO STUDY

Harshada B. Gaikwada , Neha S. Gaikwada , Manali M. Patila, Sakshi P. Patila , Somnath D. Bhingeb* and Mangesh A. Bhutkarc

a Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon- 415 404, Maharashtra, India

b Department of Pharmaceutical Chemistry, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad-415 539, Maharashtra, India

c Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon-415 404, Maharashtra , India

For Correspondence: E-mail: somu1245@yahoo.co.in

 

https://doi.org/10.53879/id.62.05.15233


ABSTRACT

One of the most common infections is helminthiasis. A significant section of the global population is affected by this degenerative illness. Comparative research was initiated to examine the anthelmintic potential of extracts of green and red leaves of Terminalia catappa against Indian earthworm Pheretima posthuma. Two concentrations (25 and 50 mg mL-1) of aqueous and alcoholic T. catappa extracts from both leaves were evaluated in an anthelmintic assay by measuring the time required for worm paralysis (P) and death (D). The red aqueous extract (25 mg mL-1) significantly reduced paralysis time vs. the standard, indicating strong anthelmintic activity, while death times were similar. At 50 mg mL-1, both red aqueous and ethanolic extracts shortened paralysis and death times, highlighting their efficacy against parasites. This study revealed that the aqueous and alcoholic T. catappa extracts effectively induced worm paralysis and, at higher concentrations, led to worm death more efficiently than the standard drug.

Year 2025 | Volume No. 62 | Issue No.5 | Page No. 73-76
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