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Synthesis and Biological Evaluation of 2-SubstitutedPhenyl-1-(Substituted Piperazin-1-Yl) Methyl)-1H-Benzo[D]Imidazoles

Gupta S. K., Kumar N., and Pathak D.


A series of biologically active benzimidazole derivatives (2a-2n) was synthesized by the reaction ofo-phenylenediamine with the derivatives of benzoic acid in presence of 4N-HCl followed by the reactionwith piperazine and formaldehyde to undergo Mannich reaction. The structures of all the synthesizedMannich bases were characterized by UV, FTIR, 1H NMR, mass spectroscopy and elemental analysis.The compounds were evaluated for their anthelmintic activity by the identification of paralyzing and deathtime by using mebendazole as standard in the concentration of 2mg/ml. The compounds 2a, 2b, 2e and2h were found to be most potent for anthelmintic activity. All the compounds were also evaluated forantibacterial activity against gram-positive bacterial strains like Bacillus subtilis and Streptococcus aureus,and gram-negative bacterial strains like Escherichia coli and Pseudomonas aeruginosa. The study wasperformed through disc diffusion method by using Ciprofloxacin as standard in the concentration of 50?g/ml. The compounds 2e, 2h, 2k, 2l and 2m were found to possess significant antibacterial activity.
Year 2013 | Volume No. 50 | Issue No.1 | Page No. 50
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