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Effect of Hydrophilic Polymers on Controlled Release Matrix Tablets of Acyclovir

Ashok Kumar P. and Damodar Kumar S.


Acyclovir was formulated as oral controlled release matrix tablets using natural and synthetic polymersseparately or in combinations. Tablets were prepared by direct compression method. The tablets wereevaluated to thickness, weight variation test, drug content, hardness, friability and in vitro release studies.All the formulations showed compliance with pharmacopoeal standards. The tablets prepared with variouscombination of hydroxy propyl methylcellulose (HPMC K100), locust bean gum (LBG) and karaya gum(KG) failed to produce the desired controlled release. Dissolution studies indicated that formulationF5 was most successful of the study. The formulation F5 exhibited anomalous (non-Fickian) diffusionmechanism. Based on the results of in-vitro studies it was concluded that the hydrophilic polymers canbe used as an effective matrix former to provide controlled release of acyclovir. SEM images of tabletafter dissolution showed pore formation. FT-IR and DSC study did not show any possibility of interactionbetween acyclovir and excipients.
Year 2013 | Volume No. 50 | Issue No.1 | Page No. 42
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