ABSTRACT

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.