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Evaluation of immunomodulatory activity of Hibiscus rosa sinensis (Jaswand) by ethanol-induced immunosuppression in rats

Desai S. K.*, Mulgaonkar S.S. and Pandey C. H.

K. M. Kundnani College of Pharmacy 23-Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai- 400005, India *E-mail:


The present study was planned to evaluate and compare the immunomodulatory activity of ethyl acetateextract (EAE 100 mg/kg p.o.) and standardized extract of H. rosa sinensis in terms of cyanidin chloride(SEC 4 and 8 mg/kg p.o.) from petals of H. rosa sinensis. Immunosuppression was induced by chronicadministration of ethanol whereas treated groups received ethanol concurrently with either extracts orstandard drug for 28 days. Biochemical parameters like lipid peroxidation (LPO), reduced glutathione(GSH), superoxide dismutase (SOD) and catalase (CAT) activities were assessed in blood. Spleen andthymus were examined for histopathology. Chronic administration with ethanol showed drastic decreasein the levels of SOD, CAT and GSH but highly raised levels of LPO. Administration of EAE and SECrestored to near normal the markers of oxidative stress which could further prevent ethanol induceddamage due to immunological and oxidative stress.
Year 2014 | Volume No. 51 | Issue No.02 | Page No. 21-28
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