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Investigation of Solubility Enhancement of Prasugrel Hydrochloride: Nanosuspensions and Cyclodextrin Inclusion Complexes

Devara R. K., Reddipogu P., Kumar S., Rambabu B., Jithan A.* and Habibuddin M.

Mother Teresa College of Pharmacy NFC Nagar, RR Dist, 501301, Andhra Pradesh, India *E-mail:


The objective of this study was to investigate nanosuspensions, hydroxypropyl-?-cyclodextrin (HP?CD)complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl)so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were preparedusing evaporative precipitation method. HP?CD inclusion complexes of PHCl were prepared usingphysical mixture, co-evaporation and kneading methods. Powders of the pure drug with different SLSamounts were prepared. The formulations were characterized using techniques such as powder x-raydiffractometry, scanning electron microscopy, in vitro dissolution and in vivo absorption in rats. Tofurther aid in the betterment of development of nevirapine nanosuspension, in vitro in vivo correlation(IVIVC) was established using deconvolution technique. Nanosuspensions and HP?CD inclusioncomplexes of PHCl were successfully prepared. The dissolution rate and oral absorption of PHCl inthe form of nanosuspensions was significantly higher than that of HP?CD complexes, SLS powdersas well as pure drug. All the techniques investigated in this study can be used to enhance dissolutionrate and oral absorption of prasugrel HCl and thus can reduce the fluctuations in its oral bioavailability.Nanosuspensions demonstrated to be better and superior technique when compared to other techniquesinvestigated in enhancing oral bioavailability of PHCl. IVIVC that could aid in further formulationdevelopment of PHCl nanosuspension was successfully developed using a deconvolution approach
Year 2014 | Volume No. 51 | Issue No.02 | Page No. 29-38
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