Article Details

Synthesis of some novel 1,2,4-Triazole analogues as potential anti-tubercular agents

Somani R. R.*, Shinde G. K., Shirodkar P.Y. and Sanap G. J.

Department of Pharmaceutical Chemistry VES College of Pharmacy Hashu Advani Memorial Complex Collectors Colony, Chembur (E) Mumbai- 400 074, India.

*E-mail: rakeshrsomani@gmail.com


ABSTRACT

A series of 5-(N-substituted carboxamidoethylthio)-3-(3’pyridyl)-4-amino-1,2,4-triazole derivatives (6a-j) were synthesized and evaluated for anti-tubercular activity. The derivatives were purified and structures were elucidated by spectral and elemental analyses. They were screened in-vitro at 10µg/mL concentration against Mycobacterium tuberculosis H37RV (ATCC 27294). Compounds 6e and 6h were found active as they exhibited IC50 and IC90 values at < 100µg/mL.

Year 2014 | Volume No. 51 | Issue No.01 | Page No. 41-47
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