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EVALUATION OF ANTIARTHRITIC ACTIVITY OF YOGRAJ GUGGUL FORMULATION IN FREUNDS ADJUVANT INDUCED POLY-ARTHRITIC RAT MODEL

Kaneria M., Sharma G., Wadekar R. R., Pereira M. and Naik S. R.*

Sinhgad Institute of Pharmaceutical Sciences (SIPS) Kusgaon (Bk), Off Mumbai- Pune Expressway, Lonavala, Pune 410 401, India *E-mail: srnaik5@rediffmail.com


ABSTRACT

The paper discusses evaluation of antiarthritic activity of Yograj guggul formulation in freunds adjuvantinduced poly-arthritis rat model. The findings demonstrate that the treatment with Yograj guggulformulation (200, 400 mg/kg/day) for 14 days produced a significant anti-arthritic activity (decreasedarthritic index), inhibited connective tissue metabolism (reduced hydroxyproline and hexosamine contentof edematous tissue) and caused haematological alterations (WBC, RBC, ESR and differential cell count)occur during Freunds adjuvant induced polyarthritis in rats. The antiarthritic effect of Yograj guggulformulation at 400 mg/kg was comparable to that of reference drug, diclofenac sodium (10 mg/kg). Theantiarthritic activity observed in the present study may be attributed to the various herbs present in theformulation. It is proposed that, the Yograj guggul formulation elicited antiarthritic activity largely due tothe prevention of connective tissue breakdown, decreased capillary permeability and improvement ofimmune system.
Year 2014 | Volume No. 51 | Issue No.02 | Page No. 47-53
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