Article Details

VALIDATED SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF OLMESARTAN MEDOXOMIL IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM

Rao S. Y*., Gandi P., Rao V. P. K., Kumar H. T.

Vignan Institute of Pharmaceutical Technology Beside VSEZ, Duvvada, Visakhapatnam-530 049, Andhra Pradesh, India. E-mail: yarraguntla@rediffmail.com


ABSTRACT

Two simple, sensitive and rapid spectrophotometric methods have been developed for the estimation of Olmesartan medoxomil in bulk and pharmaceutical formulation. Method A is a UV spectrophotometric method in which isopropyl alcohol is used as solvent and exhibited absorption maxima at 285 nm. Beer’s law obeyed in the concentration range of 2 - 12 μg/mL with a correlation coefficient of 0.999. Method B is visible spectrophotometric method based on charge transfer complexation which involves the formation of a yellow colored chromogen when treated with picric acid. The chromogen exhibit absorption maxima at 421 nm and obeyed Beer’s law in concentration range 4-16 μg/mL with a correlation coefficient of 0.999. The results of the methods have been validated statistically and by recovery studies confirmed the accuracy and precision of the methods. The proposed methods are simple, sensitive and economical for quantitative determination of Olmesartan medoxomil in bulk drug and pharmaceutical formulation.
Year 2015 | Volume No. 52 | Issue No.1 | Page No. 33-39
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