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Synthesis, Spectral Studies and Antianxiety Activity of Some Schiff bases of 4-(amino)-5-phenyl-4H-1,2,4-triazole-3-thiols

Wadher S. J*., Kalyankar T. M., Puranik M. P., Jangam S. B. and Yeole P. G.

School of Pharmacy Swami Ramanand Teerth Marathwada University, Nanded - 431 606, Maharashtra, India.




A series of 4-(4-substituted benzylideneamino)-5-phenyl-4H-1,2,4-triazole-3-thiols (IVa-e) was obtained by reaction of 4-(amino)-5-phenyl-4H-1,2,4-triazole-3-thiol with aromatic aldehyde in presence of concentrated sulphuric acid. The synthesised compounds were characterized by FT-IR, 1H-NMR and mass spectra data. The compounds (IVa-e) were screened for their antianxiety activity. Among the compounds, IVa and IVe were found to be the most acitive antianxiety compounds.

Year 2015 | Volume No. 52 | Issue No.12 | Page No. 56-59
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