Article Details

SOLUBILITY ENHANCEMENT OF OFLOXACIN BY MIXED SOLVENCY APPROACH

Gadade D. D.a*, Lohade T. S.a, Lahoti S. R.a,b, Rawat S. S.a and Maheshwari R. K.c

a Shri Bhagwan College of Pharmacy, Cidco-N6, Aurangabad - 431 001, Maharashtra, India.
b Y. B. Chavan College of Pharmacy, Rauza Baug, Aurangabad -431 001, Maharashtra, India.
c S. G. S. Institute of Pharmaceutical Sciences, 23, Park Road, Indore - 452 003, Madhya Pradesh, India.


* For correspondance: Email: deeps_cpn@yahoo.co.in

 

https://doi.org/10.53879/id.55.06.10738


ABSTRACT

In current study we attempted mixed solvency approach for solubility enhancement of poorly water soluble drug, ofloxacin. Various hydrotropic agents including sodium benzoate, urea, sodium citrate, sodium acetate, niaciniamide, Lignocaine hydrochloride, PEG6000, PEG-400 were evaluated under study for enhancing solubility of drug. Further effect of various blends of these hydrotropic agents on solubility of ofloxacin was studied. Aqueous injection of ofloxacin was prepared and evaluated for its antimicrobial effectiveness and stability. It was found that mixed solvency approach is useful in solubility enhancement of ofloxacin without affecting its antimicrobial properties.

Year 2018 | Volume No. 55 | Issue No.06 | Page No. 34-40
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