Article Details

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF SATRANIDAZOLE FROM ITS FORMULATION

Shirode A. R.a*, Dhumal A. P.a and Kadam V. J.a

a Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, C.B.D. Belapur, Navi Mumbai - 400 614, Maharashtra, India
* For Correspondence: E-mail - arsprojects2014@gmail.com


ABSTRACT

A sensitive stability-indicating high performance liquid chromatography (HPLC) method was developed and validated for quantitative estimation of satranidazole (SAT), a new nitroimidazole with potent antiamoebic activity and accessible in market as tablet and dry syrup either alone or in combination with ofloxacin. The present study involves the development of simple, accurate, precise, reproducible reversed phase high performance liquid chromatography (RP-HPLC) method for determination of satranidazole from its formulation. Isocratic elution at a flow rate of 1.0 mL/min was employed on Hemochrom Intsil C-18 (250 mm× 4.6 mm, 5

Year 2018 | Volume No. 55 | Issue No.10 | Page No. 40-48
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