a Dept. of Pharmaceutical Chemistry, MarathwadaMitra Mandal’s College of Pharmacy, Sr.No. 4/17, Sector No. 34, PCNTDA, Off KalewadiPhata-Pimpri Road, Thergoan (Kalewadi), Pune – 411 033, Maharashtra, India
b Dept. of Pharmaceutical Chemistry, Dnyanvilas College of Pharmacy, Gat No. 76, Dudulgaon, Pimpri – Chinhwad Corporation Area, Moshi- Alandi Road, Pimpri – Chinchwad – 412 105, Maharashtra, India
c Dept. of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune- 411 018, Maharashtra, India
*For Correspondence: E-mail: sampadadalvi17@gmail.com
https://doi.org/10.53879/id.58.11.11899
ABSTRACT
Accurate, sensitive, and economical procedures for simultaneous estimation of pregabalin and methylcobalamine in tablet dosage form have been developed. The method employed is simultaneous equation method. This method employs the formation and solving of simultaneous equation using 528 nm and 568 nm as the two wavelengths for forming equation. Drugs obey Beer’s law in the concentration range 10-50 µg mL-1 for pregabalin and 10-50 µg mL-1 for methylcobalamine. The proposed spectrophotometric method was validated and successfully applied for the assay of both drug combinations in several laboratory prepared mixtures and commercial tablets
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