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PANCREATIC LIPASE INHIBITORY AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF FLORETS OF ASTER SPECIES

Shahu R. R.b, Rathod P.a,b, Kulkarni C.a,b, Mhatre S.a,b and Yadav R. P.a,b*

a MGMIHS OMICS Research Center, MGM Central Research Laboratory, MGM Medical College and Hospital, MGM Institute of Health Sciences, Sector 1, Kamothe, Navi Mumbai - 410 209, Maharashtra, India
b Department of Medical Biotechnology, MGM School of Biomedical Sciences, MGM Institute of Health Sciences Sector-1, Kamothe, Navi Mumbai - 410 209, Maharashtra, India
* For Correspondence E-mail : raman.yadav@mgmmumbai.ac.in


ABSTRACT

Pancreatic lipase inhibitory effect of methanolic extract of florets Aster sp. was studied. In case of Aster sp. (White florets) the pancreatic lipase inhibition recorded was 82.75% with an IC50 value of 38μg/mL. Aster sp. (light pink) showed 80.04 % inhibition with an IC50 of 72 μg/mL. On 2 h dialysis, both the extracts lost their significant pancreatic lipase inhibitory activity, indicating the reversible nature of inhibition. pH slightly affected the performance of pancreatic lipase inhibitory activity. Extract (white florets) also showed 22.03% superoxide radical scavenging activity and 22.73% free radical scavenging activity indicating the multifunctional nature of the extract. Light pink florets showed 40.67% superoxide radical scavenging activity and 24.10% free radical scavenging activity. Saponin and alkaloid molecule in white florets of Aster sp. and alkaloid in light pink florets were identified as active principles for pancreatic lipase inhibitory activity.

Year 2018 | Volume No. 56 | Issue No.12 | Page No. 60-68
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