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Since the time the COVID-19 pandemic hit, the whole world is racing to develop vaccines. Vaccines that are in the development stage are also not a panacea. Preliminary studies have revealed that the ‘antibodies’ formed post vaccinations do not last long, vaccination with ...

Development of drugs against diabetes has always remained a big challenge among the medicinal chemists around the globe because of its continuously increasing prevalence worldwide. The emergence of benzothiazole as a prominent lead against diabetes is credited to the development of the aldose red...

Compound-1, was synthesized by the reaction of carbazole with chloroacetyl chloride in dry acetone. Compound 1 on reaction with hydrazine hydrate yielded compound 2, which on reaction with various substituted phenyl isothiocyanates in absolute alcohol yielded compounds 3-8 i.e.2-(carbazolylacetyl...

Histone deacetylase (HDAC) inhibitors have been established as a novel class of anticancer agents. The HDAC enzyme plays a vital role in gene transcription for regulation of cell proliferation, migration and apoptosis, immune pathways and angiogenesis. In this work, a series of 49 hydroxamate der...

The roots of Hemidesmus indicus, belonging to the family Ascelpidaceae, are used as blood purifier, antileucorrhoeic, galactogenic, antidiarrhoeal, antirheumatic, antisyphilitic, febrifuge and possesses chemical constituents like triterpenoids (lupeol), flavonoids, glycosides and tannins. Roots w...

A rapid, simple and precise reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the estimation of edoxabantosylate in tablets. The quantification was carried out using a Phenomenex C-18 column (250×4.6 mm i.d., 5µm particle size) in isocratic mode with mobil...

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of fo...

This study was undertaken to investigate the in vivo wound healing activity of ethanol extracts of the aerial parts of Euphorbia hirta Linn. and its polyherbal formulation with Tridax procumbens and Eclipta alba. The in vivo wound healing activity was assessed in albino rats by using three wound ...

Tukhme Karafs is the seed of Apium graveolens L., which is an important aromatic plant grown globally as a fresh herb and widely used as salad crop. This seed possesses potential pharmacological activity like hepatoprotective, diuretic and lithotriptic. The present study was designed to evaluate ...

Deflazacort is a poorly water-soluble drug and is practically insoluble in water. The objective of this study was to improve the solubility of deflazacort by using as solubility enhancer β-cyclodextrin and also to study the effect of the water-soluble polymer PEG 400...

A series of new 1,3,4-oxadiazoles (3a-j) was synthesized by reacting Schiff’s bases (2a-j). The Schiff’s bases (2a-j) underwent selective cyclization with chloramine-T to yield the 1,3,4-oxadiazoles (3a-j). Newly synthesized compounds were characterized by spectral studies.